Maximizing gas throughput in transmission networks under hydraulic and operational constraints is a combinatorial problem whose complexity grows exponentially with network size, making it computationally intensive to solve exactly. This paper addresse
Maximizing gas throughput in transmission networks under hydraulic and operational constraints is a combinatorial problem whose complexity grows exponentially with network size, making it computationally intensive to solve exactly. This paper addresses the graph-based optimization problem by optimizing nodal-pressure assignments under the Panhandle-B hydraulic equation. By framing the problem as a search over discretized nodal-pressure assignments coupled with a cost Hamiltonian that encodes both the delivery objective and physical-constraint penalties, we establish a unified formulation suitable for the Quantum Approximate Optimization Algorithm (QAOA). The mathematical model is adapted to a Quadratic Unconstrained Binary Optimization (QUBO) formulation and implemented using the Classiq quantum software platform. In simulator-based experiments, QAOA recovered the maximum-throughput valid operating point, consistent with classical exhaustive evaluation and classical hydraulic simulation reference solutions. A distinctive contribution of this work is the end-to-end execution of a reduced problem instance on the IonQ Forte-1 trapped-ion quantum processor. Remarkably, the hardware implementation used only p=2 QAOA layers, substantially fewer than the p=30 layers used in the simulator-based study. Despite this significant reduction in circuit depth, the QPU produced physically valid and interpretable candidate solutions that bracketed the continuous classical optimum, with each located within one pressure-discretization step of it. These results demonstrate that meaningful gas-network optimization behavior can be obtained using considerably shallower QAOA circuits than initially expected and provide an end-to-end proof of concept for near-term quantum-assisted gas-network optimization.